Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
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چکیده
منابع مشابه
Erratum: Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
Corrections Following publication of our article [1], it has come to our attention that Olivier Bourron’s name was displayed incorrectly. We publish this correction to update the author list, which is as follows: Sophie Liabeuf , Olivier Bourron , Cees Vemeer , Elke Theuwissen , Elke Magdeleyns , Carole Elodie Aubert , Michel Brazier , Romuald Mentaverri , Agnes Hartemann , and Ziad A. Massy 1,...
متن کاملVascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
BACKGROUND Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of inactive, dephospho-uncarboxylated MGP(dp-ucMGP) and total uncarboxylated MGP(t-ucMGP) and assess their links with biological and clinical parameters (including peripheral vasc...
متن کاملCirculating matrix Gla protein in patients with vascular pathology
competitive ELISA for desphosphorylated MGP (dpMGP) (Braam et al 2000) and uncarboxylated MGP (ucMGP) (Schurgers et al 2005a) and also sandwich-ELISA for desphosphorylatedcarboxylated MGP (dp-cMGP) or desphosphorylated-uncarboxylated MGP (dp-ucMGP) (Schurgers et al 2010). Several studies were established an association of these conformations with VD: low serum ucMGP was considered a potential i...
متن کاملNovel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.
OBJECTIVE Matrix gamma-carboxyglutamic acid (Gla) protein (MGP), a vitamin K-dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease. METHODS AND RESULTS Novel conformation-specific antibodies against MGP were used...
متن کاملIncreased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease
OBJECTIVE AND DESIGN Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arteries, is increased in patients with atherosclerosis. In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were e...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2014
ISSN: 1475-2840
DOI: 10.1186/1475-2840-13-85